Tomoki Sugiyama

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To achieve effective active targeting in a drug delivery system, we previously developed dual-targeting (DT) liposomes decorated with both vascular endothelial growth factor receptor-1 (VEGFR-1)-targeted APRPG and CD13-targeted GNGRG peptide ligands for tumor neovessels, and observed the enhanced suppression of tumor growth in Colon26 NL-17 tumor-bearing(More)
A single-electrode voltage-clamp technique was employed on in vitro hippocampal slices to investigate the membrane current responsible for the slow afterhyperpolarization (AHP) in CA3 pyramidal cells and the effects of monoamines and antidepressant drugs on this current were studied. This was achieved by using conventional procedure to evoke an AHP in(More)
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