Tomohiro Takahara

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The effects of sevoflurane (0.5%, 1.5%, and 2.5%) on the spinal dorsal horn wide dynamic range (WDR) neuronal activity were studied in either spinal cord intact or spinal cord-transected cats. Extracellular activity was recorded in the dorsal horn from single WDR neurons responding to noxious and non-noxious stimuli applied to the cutaneous receptive fields(More)
Chemosensitivity test using growth chamber (GC) was executed on 7 human and murine cell lines, 16 human tumor xenografts and 60 fresh surgical specimens. Dissociated tumor cells suspended in tumor growth medium were plated into GC and incubated with a various concentration of mitomycin C (MMC), adriamycin (ADM), cisplatin (DDP) and 5-fluorouracil (5-FU).(More)
BACKGROUND Respiratory depression, such as obstruction of upper airway and inadequate ventilation, often appears during sedation and anesthesia. We studied the effect of propofol on the upper airway patency and the inspiratory drives. METHODS Experiments were performed on the adult rabbits vagotomized, paralyzed and ventilated with nitrous(More)
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