Tomohiro Taguchi

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Alexander's disease, a leukodystrophy characterized by Rosenthal fibers (RFs) in the brain, is categorized into three subtypes: infantile, juvenile, and adult. Although most are sporadic, occasional familial Alexander's disease cases have been reported for each subtype. Hereditary adult-onset Alexander's disease shows progressive spastic paresis, bulbar or(More)
Mulberry latex contains extremely high concentrations of alkaloidal sugar mimic glycosidase inhibitors, such as 1,4-dideoxy-1,4-imino-D-arabinitol (D-AB1) and 1-deoxynojirimycin (DNJ). Although these compounds do not harm the silkworm, Bombyx mori, a mulberry specialist, they are highly toxic to insects that do not normally feed on mulberry leaves. D-AB1(More)
BACKGROUND In the clinical field of jawbone formation, the use of autogenous bone as the graft material is the gold standard. However, there are some problems with this technique, such as risk of infection on the donor side, the limited amount of available bone mass, and marked resorption of the grafted bone. We investigated the potential for using teeth as(More)
In order to keep global competences, recent manufacturers have been utilizing product families to diversify and enhance the product performance by simultaneously designing multiple products under commonalization and standardization. Design information of product architecture and family is inevitably more complicated and numerous than that of a single(More)
Herein, the solid-state emission with good fluorescence quantum yields of N-Boc-indolylbenzothiadiazoles as a new class of fluorophores is described. Their solid-state emission covers the wide range of the visible spectrum and the emission color can be tuned easily by changing the substituents on the two heteroaromatic rings. Among these, 3-methylindolyl(More)
Engineering design is validated by engineering analysis. In the process for predicting the physical behavior of the design, the design components, physical mechanisms, etc. are idealized as models, the contents of which depend on a various factors such as the type of product, the validation objectives, and the design lead time as well as the design's(More)
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