Tomohiro Taguchi

Learn More
Alexander's disease, a leukodystrophy characterized by Rosenthal fibers (RFs) in the brain, is categorized into three subtypes: infantile, juvenile, and adult. Although most are sporadic, occasional familial Alexander's disease cases have been reported for each subtype. Hereditary adult-onset Alexander's disease shows progressive spastic paresis, bulbar or(More)
Rat hippocampal neurons organized complex networks on a culture dish which has 64 planar microelectrodes and the spontaneous action potentials were frequently observed. The living neuronal network was able to distinguish patterns of action potentials evoked by different inputs, suggesting that a cultured neuronal network can represent and process particular(More)
In order to keep global competences, recent manufacturers have been utilizing product families to diversify and enhance the product performance by simultaneously designing multiple products under commonalization and standardization. Design information of product architecture and family is inevitably more complicated and numerous than that of a single(More)
Engineering design is validated by engineering analysis. In the process for predicting the physical behavior of the design, the design components, physical mechanisms, etc. are idealized as models, the contents of which depend on a various factors such as the type of product, the validation objectives, and the design lead time as well as the design's(More)
  • 1