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Cramping an alkyl group by rigid macrocyclic framework
An anthracene–acetylene cyclic dimer with an intra-annular ethyl group was synthesized as a sterically congested π-conjugated compound by cyclization with Sonogashira coupling. The ethyl group was ...
Stereoselective synthesis of cis-2,5-disubstituted THFs: application to adjacent bis-THF cores of Annonaceous acetogenins.
TLDR
N-Iodosuccinimide (NIS) effectively worked as an activator of the double bonds in the substrates and the silyl enol ether to produce cis-2,5-disubstituted tetrahydrofurans in one pot via siloxy intermediates. Expand
The first asymmetric total syntheses of both enantiomers of cryptocaryone
The first asymmetric total syntheses of the (+)- and (−)-cryptocaryones are described. Removal of the acetal unit of the enone acetal 5, which was obtained in our previous study from theExpand
Asymmetric total synthesis of (-)-stenine and 9a-epi-stenine.
TLDR
The results of this effort demonstrate the applicability of the chiral auxiliary based strategy to the preparation of naturally occurring alkaloids that contain highly functionalized cyclohexane cores. Expand
Intramolecular iodoetherification of ene or diene ketals: facile synthesis of spiroketals.
A novel and rapid approach to chiral mono- or di-substituted spiroketals based on remote asymmetric induction by intramolecular iodoetherification of ene or diene ketals has been developed. ThisExpand
Synthesis and Conformational Analysis of 10-Mesitylanthracene-1,8-diyl Oligomers
Oligomers consisting of 10-mesitylanthracene-1,8-diyl units were synthesized by Ni-mediated coupling of the corresponding dibromide as new oligoarene compounds. The structures and properties of theseExpand
Intramolecular Iodoetherification of Ene or Diene Ketals: Facile Synthesis of Spiroketals.
Chiral spiroketals (II), (VI) and (IX) are synthesized based on remote asymmetric induction.