Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats.
The Spontaneously Diabetic Torii (SDT) fatty rat is expected to be a useful model for the analysis of diabetic complications and the evaluation of drugs related to metabolic diseases.
JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity.
Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.
It is concluded that the SDT rat is useful, as a model of non-obese insulin secretory disorder, for the analysis of the onset of type 2 diabetes and the development of antidiabetic agents.