Tomohiko Shimo

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Kawasaki disease (KD) is an acute systemic vasculitis associated with the development of coronary arterial lesions (CALs) occurring in 3–5% of children treated by intravenous immune globulin (IVIG). However, a considerable number of patients who are not responding to IVIG are at much higher risk. Although studies have explored potential biomarkers to(More)
Sirs, We read with great interest the article entitled “Antioxidant status of children with idiopathic nephrotic syndrome” by Mishra et al. which was recently published in Pediatric Nephrology [1]. Oxidative stress (OS), defined as a disturbance in the reactive oxygen species (ROS) and antioxidant balance, can result either from low levels of antioxidants(More)
Sirs, We read with great interest the article entitled “Acute renal failure due to obstructive uric acid stones associated with acute gastroenteritis” by Fujita et al. that was recently published in Pediatric Nephrology [1]. Here, we would like to comment on the pathogenesis of uric acid stone formation in children with human rotavirus (HRV)-associated(More)
The administration of ceftriaxone is known to be associated with biliary pseudolithiasis, although the development of urolithiasis has only rarely been reported. We treated a young male with bacterial meningitis complicated by urinary precipitates composed of ceftriaxone–calcium salt, which prompted us to study whether ceftriaxone administration predisposes(More)
Recent evidence indicates that transplanted autologous bone marrow cells (BMCs) can be converted into functional liver cells. BMC therapy can improve hepatic function and increase the potential for liver regeneration in patients with serious liver damage. We investigated whether BMC therapy influenced liver regeneration after massive hepatectomy in mice.(More)
For immunodeficient patients, fungi are life-threatening pathogens. In this paper, we present an autopsy case of combined zygomycosis and aspergillosis. A female in her 70s on chronic hemodialysis was admitted to a hospital suffering bloody sputum, dyspnea, and fever, probably due to perinuclear anti-neutrophil cytoplasmic antibody-related vasculitis.(More)
BACKGROUND Home based oral immunotherapy (OIT) for food allergy has often been used for young children in Japan, the majority of whom are believed to outgrow the allergy by the school age, therefore the true efficacy of the therapy has been controversial. The aim of this study was to evaluate the efficacy and safety of a newly developed slow- type(More)
BACKGROUND The aim of this study was to investigate the role of specific IgG4 antibodies to hen's egg white and determine their utility as a marker for the outcome of oral challenge test in children sensitized to hen's egg METHODS The hen's egg oral food challenge test was performed in 105 sensitized children without atopic dermatitis, and the titers of(More)
Recent observation revealed that serum albumin plays an important role in the host defense mechanism as it is one of the important antioxidants. This study was conducted to investigate whether hypoalbuminemia contributes to a decreased biological antioxidant potentials (BAP) in idiopathic nephrotic syndrome (INS). Fifty three heparinised blood samples were(More)
Pulmonary sclerosing hemangioma (SH) is an uncommon benign or low-grade malignant tumor. Multicentric SH and SH with lymph node metastasis have rarely been reported. The present report describes a case of pulmonary SH with lymph node metastasis in a middle-aged female. A nodule was found incidentally in the lower left lung. The patient underwent left lower(More)