Haruo Hanyu21
Toshihiko Iwamoto21
Kentaro Hirao13
Hidekazu Kanetaka10
Soichiro Shimizu9
21Haruo Hanyu
21Toshihiko Iwamoto
13Kentaro Hirao
10Hidekazu Kanetaka
9Soichiro Shimizu
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PURPOSE To determine the relationship of differing levels of education on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD). METHODS Fifty-three patients with AD followed-up for an average of 36 months were divided into the high-educated group (HE, >or=12 years of schooling) and low-educated group (LE, <12 years of schooling).(More)
Evi-1 has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) in Evi-1-deficient embryos are severely reduced in number with defective proliferative and repopulating capacity. Selective ablation of Evi-1 in Tie2(+) cells mimics Evi-1 deficiency, suggesting(More)
Ecotropic viral integration site 1 (Evi1), a transcription factor of the SET/PR domain protein family, is essential for the maintenance of hematopoietic stem cells (HSCs) in mice and is overexpressed in several myeloid malignancies. Here, we generate reporter mice in which an internal ribosome entry site (IRES)-GFP cassette is knocked-in to the Evi1 locus.(More)
BACKGROUND AND PURPOSE The progression of cognitive deterioration in patients with Alzheimer's disease (AD) is considerably variable. The ability to predict the progression rate is important for clinicians to treat and manage patients with AD. We examined the possible relationship between the rate of cognitive deterioration and regional cerebral blood flow(More)
OBJECTIVE We performed combined studies of magnetic resonance imaging (MRI) analysis of the substantia innominata and single photon emission CT (SPECT) measurement of cerebral perfusion with the goal of predicting which patients with Alzheimer's disease are most likely to respond to donepezil treatment. METHODS Ninety-one patients treated with donepezil(More)
BACKGROUND/AIMS To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD). METHODS We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method. RESULTS Statistical maps(More)
AIM Some patients with mild cognitive impairment (MCI) may have impaired frontal lobe function. To assess the frontal lobe functions of subjects with MCI using the Frontal Assessment Battery (FAB) and to identify the brain regions responsible for FAB performance. METHODS Based on the FAB score cut-off of 12/13, 38 MCI subjects were divided into a high FAB(More)
OBJECTIVE Dementia with Lewy bodies (DLB) is generally characterized by a decrease in regional cerebral blood flow (rCBF) in the occipital lobe. However, not all patients with DLB have this feature. We explored characteristics of rCBF pattern changes to improve the identification of DLB, in addition to occipital hypoperfusion. METHODS The study population(More)