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The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats.
TLDR
It is concluded that inhibition of p300 HAT activity by the nontoxic dietary compound curcumin may provide a novel therapeutic strategy for heart failure in humans. Expand
Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet.
TLDR
These findings provide the first evidence for the up-regulated expression of miR-143 in the mesenteric fat of high-fat diet-induced obese mice, which might contribute to the regulated expression of adipocyte genes involved in the pathophysiology of obesity. Expand
Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects
TLDR
It is demonstrated that V EGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis. Expand
The Discovery of LOX-1, its Ligands and Clinical Significance
TLDR
Evidence has been accumulating that LOX-1 recognizes not only oxLDL but other atherogenic lipoproteins, platelets, leukocytes and CRP, which contributes to atherosclerotic plaque formation, thrombogenesis,Leukocyte infiltration and myocardial infarction, which determine mortality and morbidity from atherosclerosis. Expand
MicroRNA-27a Regulates Beta Cardiac Myosin Heavy Chain Gene Expression by Targeting Thyroid Hormone Receptor β1 in Neonatal Rat Ventricular Myocytes
TLDR
Findings suggested that miR-27a regulates β-MHC gene expression by targeting TRβ1 in cardiomyocytes, a bioinformatics screening using TargetScan suggested that specific miRNAs could upregulate the β- MHC gene. Expand
Identification of p300-targeted Acetylated Residues in GATA4 during Hypertrophic Responses in Cardiac Myocytes*♦
TLDR
It is shown that 4 lysine residues located between amino acids 311 and 322 are required for synergistic activation of atrial natriuretic factor and endothelin-1 promoters by GATA4 and p300, and the most critical lysines acting as p300-mediated acetylation targets in Gata4 during hypertrophic responses in cardiac myocytes are identified. Expand
Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans
TLDR
The results suggest the body wall genes have evolved following duplication of the pharynx gene and provide important data about gene duplication and functional differentiation of nematode troponin I isoforms. Expand
Cyclin-dependent Kinase-9 Is a Component of the p300/GATA4 Complex Required for Phenylephrine-induced Hypertrophy in Cardiomyocytes*
TLDR
It is demonstrated that Cdk9 forms a functional complex with the p300/GATA4 and is required for p300-induced transcriptional activities, DNA binding, and acetylation of GATA4- transcriptional pathway during cardiomyocyte hypertrophy. Expand
MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells.
TLDR
The results of luciferase assays revealed that miR-1 recognizes and targets the 3' untranslated region of cyclin-dependent kinase-9 (Cdk9) in ES cells, and Cdk9 may be involved in this process as a target of miR -1. Expand
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