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  • Takami Akagi, Xin Wang, Tomofumi Uto, Masanori Baba, Mitsuru Akashi
  • Materials Science, Medicine
  • Biomaterials
  • 2007 (First Publication: 1 August 2007)
  • Induction of an adaptive immune response by vaccination is possible for a broad range of infectious diseases or cancers. Antigen-loaded polymeric nanoparticles have recently been shown to possessContinue Reading
  • Tomofumi Uto, Xin Wang, +4 authors Masanori Baba
  • Biology, Medicine
  • Journal of immunology
  • 2007 (First Publication: 1 March 2007)
  • Nanoparticles are considered to be efficient tools for inducing potent immune responses by an Ag carrier. In this study, we examined the effect of Ag-carrying biodegradable poly(gamma-glutamic acid)Continue Reading
  • Xin Wang, Tomofumi Uto, Takami Akagi, Mitsuru Akashi, Masanori Baba
  • Biology, Medicine
  • Journal of virology
  • 2007 (First Publication: 15 September 2007)
  • The mainstream of recent anti-AIDS vaccines is a prime/boost approach with multiple doses of the target DNA of human immunodeficiency virus type 1 (HIV-1) and recombinant viral vectors. In thisContinue Reading
  • Fumiaki Shima, Tomofumi Uto, Takami Akagi, Mitsuru Akashi
  • Medicine, Chemistry
  • Bioconjugate chemistry
  • 2013 (First Publication: 19 June 2013)
  • CpG oligodeoxynucleotide (ODN) encapsulated poly(γ-glutamic acid)-graft-l-phenylalanine ethyl ester (γ-PGA-Phe) nanoparticles (NPs) employing polycations were prepared to develop vaccine delivery andContinue Reading
  • Fumiaki Shima, Tomofumi Uto, Takami Akagi, Masanori Baba, Mitsuru Akashi
  • Materials Science, Medicine
  • Acta biomaterialia
  • 2013 (First Publication: 1 November 2013)
  • We prepared size-regulated nanoparticles (NPs) composed of amphiphilic poly(γ-glutamic acid) (γ-PGA). In this study, 40, 100 and 200 nm γ-PGA-graft-l-phenylalanine ethylester (γ-PGA-Phe) NPs wereContinue Reading
  • Ai Himeno, Takami Akagi, +8 authors Mitsuru Akashi
  • Biology, Medicine
  • Vaccine
  • 2010 (First Publication: 1 July 2010)
  • We previously reported that biodegradable amphiphilic poly(gamma-glutamic acid) nanoparticles (NPs) carrying the recombinant gp120 env protein of the human immunodeficiency virus type 1 (HIV-1) wereContinue Reading