Tomoaki Okada

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BACKGROUND Fabric-like hemostatic dressings offer promise for hemorrhage control in noncompressible areas, especially given their similarity in form to standard gauze currently in use. Recently, two such products, Combat Gauze (CBG) and TraumaStat (TMS), were introduced. Their performance is evaluated in two vascular injury models. MATERIALS AND METHODS(More)
Primary aldosteronism (PA) has been recognized as a relatively benign form of hypertension associated with a low incidence of vascular complications. Recent reports, however, indicate that cerebrovascular accidents are common in PA. We report a case of multiple aneurysms with PA in a middle-aged woman who presented with subarachnoid hemorrhage. A(More)
This report entails in vivo and in vitro studies concerned with free radical species involved in brain ischemia. The participation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the early manifestation of cerebral ischemia/reperfusion was investigated in gerbils exposed to transient global ischemia using(More)
Anomalous origin of the coronary arteries (ACA) is relatively uncommon and occurs in 0.3—2.5% of patients [1—3]. The approximate incidence of a single coronary ostium ranges from 0.03% to 0.07% [1,4,5]. Some of these ACA are clinically benign or associated with specific congenital defects, whereas others can cause myocardial ischemia, infarction, syncope,(More)
OBJECTIVES An advanced hemostatic dressing, Rapid Trauma Hemostat (RTH), was developed using nano-engineered inorganic nanofibers with hemostatic surface properties. METHODS Yorkshire swine were treated with RTH or Combat Gauze (CBG) to stop bleeding from either an arterial puncture (G-RTH and G-CBG) or a liver lobe laceration (L-RTH and L-CBG). All(More)
BACKGROUND Atrial fibrillation (AF) is associated with endothelial dysfunction. Studies have shown the incidence of cardiovascular events to be greater in patients with persistent AF (PeAF) than paroxysmal AF (PAF). OBJECTIVE The aim of this study was to investigate whether endothelial dysfunction and the impact of catheter ablation on the endothelial(More)
In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed,(More)
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