Tomoaki Fukuda

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We describe the results of clinical, serological, and immunological studies in a Japanese traveler with dengue fever (DF). DF was confirmed by isolation of dengue virus from the serum, a positive direct reverse-transcription polymerase chain reaction (RT-PCR) test, and a high titer of anti-IgM antibody to dengue virus. Interestingly, in this patient(More)
[reaction: see text] Asymmetric allylic amination of allylic carbonates prepared from racemic Morita-Baylis-Hillman adducts proceeded in the presence of Pd catalyst, chiral diaminophosphine oxide (DIAPHOX), and BSA, affording the corresponding chiral aza-Morita-Baylis-Hillman adduct derivatives in excellent yield with up to 99% ee. The cyclic reaction(More)
We describe the discovery and optimization of a novel series of furo[3,2-d]pyrimidines as G protein-coupled receptor 119 agonists. Agonistic activity of 4 (EC50=129nM) was improved by replacing the intramolecular hydrogen bond between the fluorine atom and the aniline hydrogen in the head moiety with a covalent C-C bond to enhance conformational(More)
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