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A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
- Amon Asgharpour, S. Cazanave, +15 authors A. Sanyal
- Medicine, Biology
- Journal of hepatology
- 31 May 2016
Background & Aims The lack of a preclinical model of progressive non-alcoholic steatohepatitis (NASH) that recapitulates human disease is a barrier to therapeutic development. Methods A stable… Expand
Vitamin E and nonalcoholic fatty liver disease
Purpose of reviewOxidative stress plays a central role in the transition from simple steatosis to nonalcoholic steatohepatitis (NASH). An effective therapeutic strategy is to target reduction in… Expand
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in… Expand
Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease.
- H. Min, F. Mirshahi, +8 authors A. Sanyal
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 May 2015
The status of the GP130-STAT3 signaling pathway in humans with nonalcoholic fatty liver disease (NAFLD) and its relevance to disease pathogenesis are unknown. The expression of the gp130-STAT3 axis… Expand
The cardiovascular link to nonalcoholic fatty liver disease: a critical analysis.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and can progress from simple steatosis to nonalcoholic steatohepatitis and finally to liver… Expand
Recent advances in understanding/management of non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) can lead to advanced fibrosis, hepatocellular carcinoma, and end-stage liver disease requiring liver transplantation. A myriad of pathways and genetic influence… Expand
Activation of the GP 130-STAT 3 axis and its potential implications in nonalcoholic fatty liver disease
Hae-Ki Min,* Faridoddin Mirshahi, Aurora Verdianelli, Tommy Pacana, Vaishali Patel, Chun-Geon Park, Aejin Choi, Jeong-Hoon Lee, Chung-Berm Park, Shunlin Ren, and Arun J. Sanyal* Division of… Expand
- Open Access
A Lipidomic Readout of Disease Progression in A Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease.
Multiple changes in lipid metabolism occur in nonalcoholic fatty liver disease. However, it is not known which of these contribute to disease progression. The objective of this study was to define… Expand
242 EFFECT OF HIGH-DOSE RIBAVIRIN (RBV), ALINIA (NITAZOXANIDE) AND PEGYLATED INTERFERON (PEGIFN) ALFA-2A IN ATTAINING SUSTAINED VIROLOGIC RESPONSE (SVR) IN TREATMENT OF CHRONIC HEPATITIS C
241 REDUCING ALPHA-FETOPROTEIN WITH INTERFERON THERAPY SUPPRESSES HEPATOCARCINOGENESIS IN HEPATITIS C VIRUS-INFECTED PATIENTS WHO ARE VIROLOGICAL RESPONDERS AND NON-RESPONDERS Y. Asahina, K.… Expand