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BACKGROUND Recent work suggests that heavy use of cannabis is associated with an increased risk of schizophrenia-like psychosis. However, there is a dearth of experimental studies of the effects of the constituents of cannabis, such as Delta9-tetrahydrocannabinol (THC). In a study of intravenous (i.v.) synthetic THC in healthy humans, we aimed to study the(More)
To examine possible mechanisms for the association between cigarette smoking and reduced fertility, we have measured the concentration of the nicotine metabolite cotinine in ovarian follicular fluid collected at the time of oocyte recovery during treatment for in-vitro fertilisation. In a group of women in whom follicular fluid cotinine could not be(More)
We analysed solid dose formulations retrieved from an amnesty bin at a London dance venue, into which visitors were required to discard illicit drugs and into which security staff place substances found during searches. We obtained a Home Office licence to analyse the contents of the bin, which were removed in the presence of a police officer and sealed in(More)
mus Using HPLC with Mass Spectrometric Detection, David W. Holt, Terry Lee, Kirsty Jones, and Atholl Johnston ( St. George’s Hospital Medical School, London SW17 0RE, United Kingdom; 2 St. Bartholomew’s & The Royal London School of Medicine & Dentistry, London EC1M 6BQ, United Kingdom; * address correspondence to this author at: Analytical Unit, St.(More)
It is now common practice to measure immunosuppressive drugs in blood as a guide to therapy. The immunosuppressive drug sirolimus, recently approved for use following kidney transplantation, was developed in the context of this clinical approach. Throughout the early clinical studies, validated analytical techniques based on chromatographic techniques were(More)
OBJECTIVE This study assessed the performance characteristics of a new microparticle enzyme immunoassay (MEIA) for the determination of sirolimus in whole blood. BACKGROUND In clinical investigatory studies, dose adjustments of the immunosuppressive drug sirolimus have been carried out using either high-performance liquid chromatography (HPLC) or, more(More)
Recipients of organ transplants remain particularly dependent on prednisolone as part of their maintenance immunosuppression. Despite this, the pharmacokinetics of prednisolone have never been fully characterized in these patients, and consequently dosing remains empirical. Accurate monitoring of prednisolone, its primary metabolite prednisone, and(More)
BACKGROUND Many patients with venous leg ulcers do not heal with standard care. HP802-247 is a novel spray-applied cell therapy containing growth-arrested allogeneic neonatal keratinocytes and fibroblasts. We compared different cell concentrations and dosing frequencies of HP802-247 for benefit and harm when applied to chronic venous leg ulcers. METHODS(More)
A 24-year-old man was admitted to our coronary care unit with a transmural lateral wall myocardial infarction 48 hours after the onset of a viral illness. Coronary angiography two months following the patient's discharge from the hospital disclosed normal left ventricular wall motion and coronary anatomy. The pathophysiologic mechanisms of myocardial(More)