Tomihiko Tanino

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PURPOSE To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms in Japanese patients with glaucoma. METHODS The OPTN gene was analyzed in blood samples from 629 Japanese subjects. There were 194 patients with primary open-angle glaucoma (POAG), 217 with normal-tension glaucoma (NTG), and 218 with(More)
Background. Abnormal optic disc excavations are reportedly seen in patients with Leber's hereditary optic neuropathy (LHON), a mitochondrial dysfunction disease. We examined the disc morphology in the eyes of patients with LHON at the atrophic stage and compared it to that in eyes with normal-tension glaucoma (NTG). Methods. We studied 15 LHON patients(More)
To evaluate the effect of unoprostone isopropyl on microcirculation in the optic nerve head (ONH) of controls and patients with normal-tension glaucoma (NTG). Thirty healthy volunteers were randomly placed in a placebo group or a control group. For ten NTG patients, one eye was selected to receive the placebo drops and the contralateral eye received the(More)
The effect of change of contrast on the pattern reversal monocular VER, binocular VER, and binocular summation (binocular VER amplitude/monocular VER amplitude) was studied in normal subjects. The monocular VER amplitudes showed significant increase until the 0.50 contrast and saturation above that contrast. The largest binocular VER amplitude was observed(More)
The pattern reversal visual evoked response (VER) was recorded under conditions of artificially unbalanced visual input between two eyes, an aniseikonia induced by size lenses that alter the perceived retinal image size without changing refraction. At 3.0% aniseikonia binocular summation started to decrease, and at 5.0% aniseikonia there was no significant(More)
The effect of mean luminosity change on pattern reversal visual evoked response (VER), especially monocular VER, binocular VER and binocular summation, was studied. The mean luminosity level was changed with the use of neutral density filters. When mean luminosity level was decreased binocularly, binocular and monocular VER amplitudes decreased and(More)
We studied the effects of unequal or unbalanced visual inputs on the binocular system of normal subjects by measuring the amplitudes of the binocularly and the monocularly recorded VER and determining the value of binocular summation. The stimuli used were patterns that were either fused or not fused, of unequal luminosity and of unequal image size. When(More)
The effects of changing spatial and temporal frequencies on the amplitude of pattern reversal monocular and binocular visual evoked response (VER) were investigated. The pattern reversal VER and the degree of binocular summation (binocular VER amplitude/monocular VER amplitude) were lowest at the spatial frequency (check size) of 0.3 cycles per degree (CPD)(More)
Alternating current stimulation of the eye generates an occipital electrically evoked response (a.c.-e.e.r.) of which the frequency characteristic shows a monophasic pattern for which the optimum stimulus frequency for evoking a maximum response is 18 Hz. A.C.-E.E.R. is a very useful tool for making a diagnosis of pigmentary retinal dystrophy and is(More)