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— Resource allocation problems are concerned with the allocation of limited resources among competing activities so as to achieve the best overall performances of the system but providing fair treatment of all the competitors. Telecommu-nication networks are facing the increasing demand for Inter-net services. Therefore, a problem of network dimensioning(More)
We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant(More)
Genetic variations in DNA repair genes may affect an individual's susceptibility to head and neck cancer. We performed a case-control study to test the association between head and neck cancer risk and two polymorphisms: the C722T of the XRCC3 and the G135C of the RAD51-genes of DNA double strand break (DSB) repair by homologous recombination (HRR).(More)
The problem of averaging outcomes under several scenarios to form overall objective functions is of considerable importance in decision support under uncertainty. The so-called Weighted OWA (WOWA) aggregation offers a well-suited approach to this problem. The WOWA aggregation, similar to the classical ordered weighted averaging (OWA), uses the preferential(More)
The approach called the Lexicographic Min-Max (LMM) optimization depends on searching for solutions minimal according to the lex-max order on a multidimensional outcome space. LMM is a refinement of the standard Min-Max optimization, but in the former, in addition to the largest outcome, we minimize also the second largest outcome (provided that the largest(More)
Telecommunication networks are facing the increasing demand for In-ternet services. Therefore, a problem of network dimensioning with elastic traffic arises which requires to allocate bandwidth to maximize service flows with fair treatment of all the services. In such applications, the so-called Max-Min Fairness (MMF) solution concept is widely used to(More)
XRCC2 and XRCC3 proteins are structurally and functionally related to RAD51 which play an important role in the homologous recombination, the process frequently involved in cancer transformation. In our previous work we show that the 135G>C polymorphism (rs1801320) of the RAD51 gene can modify the effect of the Thr241Met polymorphism (rs861539) of the XRCC3(More)
The aim of this study was to evaluate the association of polymorphisms in genes encoding three key proteins of DNA base excision repair (BER): the OGG1 Ser326Cys, the MUTYH Tyr165Cys and the XRCC1 Arg399Gln with the risk of childhood acute lymphoblastic leukemia (ALL). Our study included 97 children patients with ALL (mean age 5.4±2.5) and 131 healthy(More)
Zinc plays an essential role in a wide range of cellular processes, including defense against free radicals and maintaining genomic stability. The presence of zinc in some proteins is fundamental for their functioning as transcription factors. Little is known about interaction between zinc and DNA, which can be important in light of reports on the role of(More)
Tobacco smoking is one of the major risk factors in pathogenesis of head and neck squamous cell carcinomas (HNSCC). Many of the chemical compounds present in tobacco are well-known carcinogens which form adducts with DNA. Cells remove these adducts mainly by the nucleotide excision repair pathway (NER). NER also eliminates a broad spectrum of pyrimidine(More)