Tomasz Skórka

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A 3D spin-echo (3D SE) pulse sequence was used on a 4.7 T research MRI system to produce images of extracted human first molar tooth placed in CuSO4 water solution. The maximal resolution achieved was 35 x 63 x 300 microm3 in read and two phase directions, respectively. The high-intensity signal from water in solution together with the lack of signal from(More)
Anisotropic diffusion in the excised rat spinal cord saturated with 0.9% saline was investigated using MR microimaging with b-values up to 8000 s/mm2 for different diffusion times. Non-exponential transversal diffusion decay found in white matter (WM) and gray matter (GM) was fitted with 2 components (the "fast" and the "slow"). Significantly smaller(More)
This article presents the synthesis and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with ultrathin layer of anionic derivative of chitosan. The water-based fabrication involved a two-step procedure. In the first step, the nanoparticles were obtained by co-precipitation of ferrous and ferric aqueous salt(More)
Synopsis Diffusion anisotropy imaging (DAI) of the rat spinal cord after contusion using weight-drop method was used to study the neuro-protecting effect of 2-methyl-6-(phenylethynyl)-piridine (MPEP) – an mGlu5 receptor antagonist. 18 rats were investigated, divided into 3 groups of 6 animals: a control group with laminectomy, a reference group with injury(More)
OBJECTIVE Brain dysplasias produced by irradiation with gamma rays at various stages of prenatal development cause different post-natal susceptibility to seizures. To detect possible determinants of this difference, patterns of degenerative changes in the dysplastic brains following pilocarpine-induced epilepsy were analysed. METHODS Pregnant Wistar rats(More)
OBJECTIVE To assess alterations in perfusion and liver function in the concanavalin A (ConA)-induced mouse model of acute liver failure (ALF) using two magnetic resonance imaging (MRI)-based methods: dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA contrast agent and arterial spin labelling (ASL). MATERIALS AND METHODS BALB/c mice were studied(More)
BACKGROUND Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. METHODS PAH in rats was induced by a single subcutaneous injection of MCT (60 mg/kg).(More)
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