Tomasz P. Stefanski

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Microtubules are dynamic polymers that occur in eukaryotic cells and play important roles in cell division, motility, transport and signaling. They form during the process of polymerization of α- and β-tubulin dimers. Tubulin is a significant and heavily researched molecular target for anticancer drugs. Combretastatins are natural cis-stilbenes that exhibit(More)
Resveratrol is the most extensively studied stilbene derivative. We previously showed that methylthiostilbenes were more effective inhibitors of CYP1A1 and 1B1 activity than resveratrol. In this study, we investigated whether resveratrol and its methylthio-substituted derivatives, i.e. 3-M-4′-MTS (S2), 3,5-DM-4′-MTS (S5) and 3,4,5-TM-4′-MTS (S7) could(More)
— We provide an overview of our work to date on the parallelization of implicit time domain methods, in particular the alternating direction implicit finite-difference time-domain method (ADI-FDTD). First we describe a domain decomposition scheme for parallel ADI-FDTD in three dimensions that is suitable for implementation on widely available high(More)
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