Tomasz Mikuła

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The antiretroviral therapy has remarkably modified the process of HIV disease, enhancing higher quality of life and longer survival, however it has contemporaneously lead to the occurrence of earlier unrecognized complications, such as endothelial dysfunction and cardiovascular events. The endothelial dysfunction is directly caused by HIV-induced(More)
BACKGROUND In the era of combination antiretroviral therapy (cART), life expectancy of HIV-infected patients is the same as that of the general population, resulting in increasing prevalence of cardiovascular disease in this patient group. AIM To assess the prevalence of endothelial dysfunction in HIV-infected patients and to identify factors which affect(More)
BACKGROUND/AIM The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). PATIENTS AND METHODS Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group(More)
The purpose of the study was to evaluate routes of HBV transmission in 140 patients hospitalized in the Department of Hepatology and AIDS, Medical University of Warsaw in the years 2000--2003. Authors found two major routes of HBV infection in the observed patients: drug abuse and the unknown route in the group of young people and infection transmitted at(More)
INTRODUCTION Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression. M ethods(More)
The role of procalcitonin (PCT) in immunocompromised patients is still under investigation. This study evaluated the influence of immune deficiency on the value of PCT concentrations in the diagnosis of early stages of bacterial infections in human immunodeficiency virus (HIV)-infected patients compared with other inflammatory markers, such as C-reactive(More)
BACKGROUND There are many factors associated with human immunodeficiency virus (HIV) patients having a greater risk of cardiovascular diseases (CVD). HIV damages vessel endothelium through chronic inflammation, which, combined with dys-lipidaemia, arterial hypertension, and antiretroviral therapy leads to the progression of atherosclerotic changes. AIM(More)
I write to alert your readers to a case example of the medical sequalea associated with combined alcohol and ecstasy overdose: acute hepatitis with gall bladder inflammation in a young woman in Poland. Ecstasy (MDMA) is well known among young people in Poland and in many countries around the World. MDMA is a psychoactive substance that cause liver damage,(More)
THE AIM OF THE STUDY The aim of the study was to evaluate the spectrum of AIDS-defining malignancies (ADMs) and non-AIDS-defining malignancies (NADMs) in HIV-infected patients in Poland. MATERIAL AND METHODS A retrospective observational study was conducted among HIV-infected adult patients who developed a malignancy between 1995 and 2012 in a Polish(More)
Background: Epidemiological data from each country can differ between cities and regions, for instance morbidity in HIV infection is four times higher in the south-west of Poland than in the east parts. Newly infected people are five times more often reported in the central part of our country than in the south-east. Methods: We assessed the main reasons(More)