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- David J. Galas, Nikita A. Sakhanenko, Alexander Skupin, Tomasz M. Ignac
- Journal of Computational Biology
- 2014

Context dependence is central to the description of complexity. Keying on the pairwise definition of "set complexity," we use an information theory approach to formulate general measures of systems complexity. We examine the properties of multivariable dependency starting with the concept of interaction information. We then present a new measure for… (More)

- Tomasz M. Ignac, Alexander Skupin, Nikita A. Sakhanenko, David J. Galas
- PloS one
- 2014

Phenotypic variation, including that which underlies health and disease in humans, results in part from multiple interactions among both genetic variation and environmental factors. While diseases or phenotypes caused by single gene variants can be identified by established association methods and family-based approaches, complex phenotypic traits resulting… (More)

- Tomasz M. Ignac, Nikita A. Sakhanenko, David J. Galas
- Complexity
- 2012

- Tomasz M. Ignac, Nikita A. Sakhanenko, David J. Galas
- EURASIP J. Bioinformatics and Systems Biology
- 2012

: We describe some new conceptual tools for the rigorous, mathematical description of the "set-complexity" of graphs. This set-complexity has been shown previously to be a useful measure for analyzing some biological networks, and in discussing biological information in a quantitative fashion. The advances described here allow us to define some significant… (More)

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