Tomasz Klucznik

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Exactly half a century has passed since the launch of the first documented research project (1965 Dendral) on computer-assisted organic synthesis. Many more programs were created in the 1970s and 1980s but the enthusiasm of these pioneering days had largely dissipated by the 2000s, and the challenge of teaching the computer how to plan organic syntheses(More)
By combining chemical knowledge with network theory and chess-like algorithms, computers can, at last, design synthetic pathways to non-trivial targets. The picture shows a cost-optimized synthesis of Taxol (large yellow node) selected by the Chematica program from amongst 400+ million possibilities in just 7 s. Red nodes are commercially available(More)
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