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SPEN integrates transcriptional and epigenetic control of X-inactivation
TLDR
It is proposed that SPEN acts as a molecular integrator for the initiation of XCI, bridging Xist RNA with the transcription machinery—as well as with nucleosome remodellers and histone deacetylases—at active enhancers and promoters. Expand
NAD(P)H oxidases regulate HIF-2alpha protein expression.
TLDR
The data demonstrate that VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation. Expand
MOF-associated complexes ensure stem cell identity and Xist repression
TLDR
The regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells and neuronal progenitors is studied and it is found that both complexes influence transcription by targeting promoters and TSS-distal enhancers. Expand
NAD(P)H Oxidases Regulate HIF-2α Protein Expression*
TLDR
The data demonstrate that VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation. Expand
Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts.
TLDR
The results indicate that ADAM10 may function as the TNF sheddase in cells which lack ADAM17 activity, and the moderate silencing ofADAM10 by shRNA resulted in a significant inhibition of TNF shedding. Expand
m6A RNA methylation regulates the fate of endogenous retroviruses
TLDR
This study sheds light onto a novel function of RNA methylation in protecting cellular integrity by clearing reactive ERV-derived RNA species, which may be especially important when transcriptional silencing is less stringent. Expand
Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation
TLDR
It is proposed that, by virtue of its interaction with components of the general transcription machinery, MSL1 exists in different phosphorylation states, thereby modulating transcription in flies and causing male lethality due to a failure of dosage compensation. Expand
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.
TLDR
The data provide the first evidence that p22(phox)-based Nox oxidases maintain HIF-2alpha protein expression through inactivation of tuberin and downstream activation of ribosomal protein S6 kinase 1/4E-BP1 pathway. Expand
Functional interplay between MSL 1 and CDK 7 controls RNA polymerase II Ser 5 phosphorylation
Combinatorial action of cis-acting elements at gene promoters is the first step toward establishing efficient transcription. Accurate loading of RNA polymerase II (Pol II) at the transcription startExpand
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