Tomas Thiel

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PURPOSE Interstitial cystitis is a chronic inflammatory disease of the bladder and luminal nitric oxide has been shown to be increased in the bladder in patients with interstitial cystitis. We analyzed endogenous nitric oxide formation and inducible nitric oxide synthase gene expression in the bladder of patients with interstitial cystitis to obtain further(More)
Physiological and biochemical differences were found between normal and intragastric feeding in the rat. Milk ingested orally remained in the stomach significantly longer than milk ingested via a chronic intragastric fistula. Milk samples were removed from the stomach at intervals of 5, 20 and 45 min after ingestion and it was found that milk which had been(More)
PURPOSE Bacillus Calmette-Guérin (BCG)-treatment is an established treatment for bladder cancer, but its mechanisms of action are not fully understood. High-risk non-muscle invasive bladder-cancer (NMIBC)-patients failing to respond to BCG-treatment have worse prognosis than those undergoing immediate radical cystectomy and identification of patients at(More)
Evidence is presented that learned safety increases the rat's willingness to drink ethanol: induction of tolerance to ethanol following learned safety training produces a further increase. Rats with chronically implanted intragastric fistulae consumed substantially more (30%) alcohol when aversive post-ingestional effects were minimized by draining stomach(More)
The anti-tumour mechanisms following Bacillus Calmette-Guérin (BCG) treatment of bladder-cancer remain largely unknown. Previous studies have shown involvement of nitric-oxide (NO) formation in the BCG-mediated effect. We analyzed the effects of macrophage secreted factors (MSFs) from BCG-stimulated RAW264.7 cells on the bladder-cancer cell line MBT2.(More)
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