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The amino acids tyrosine and tryptophan are precursors of physiologically active amines in the central nervous system. To reach the brain they have to compete with other large neutral aminio acids… (More)
In order to obtain detailed information on the diurnal plasma rhythmicity in those large neutral amino acids (LNAA) which compete with each other for carrier-mediated transport from plasma into the… (More)
Male rats were given three different doses of ethanol in i.p. injections (0.66, 1.33 and 2.00 g kg-1). A dose-dependent decrease in the concentrations of most plasma amino acids was observed. For the… (More)
Administration of a low-protein diet to parkinsonian patients with "on-off" syndromes consistently increased the total daily time of "on" states when compared with a high-protein diet. The clinical… (More)
The tricyclic antidepressant amitriptyline has been shown to reduce concentrations of large neutral amino acids (LNAA) in rat plasma. Compounds with that property might interact with such amino acids… (More)
BACKGROUND Aggression has been suggested to be related to abnormal brain 5-HT activity. This amine is synthesized in brain from tryptophan, which is transported through the blood-brain barrier in… (More)
An acute dose of ethanol to man caused, within two hours, a marked decrease in most plasma amino acids.
To investigate the relation between “on-off” fluctuations in symptomatology and bioavailability of dopa in patients with Parkinson's disease, five Parkinsonian patients with pronounced “on-off”… (More)
SummaryThose large neutral amino acids (LNAA) which compete with each other for the carrier mediated transport from plasma into the brain were determined in plasma in human immunodeficiency virus… (More)
To obtain detailed data on the diurnal rhythm in rat plasma amino acids, groups of rats were killed every two hours during 24 hours and the amino acids in plasma were measured. By using such a short… (More)