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Two large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during the late 2000s with the aim to deliver a comprehensive assessment of phenotypes or to screen for robust indicators of diseases in mouse mutants. They both took advantage of available(More)
Identifying genes that are important for embryo development is a crucial first step towards understanding their many functions in driving the ordered growth, differentiation and organogenesis of embryos. It can also shed light on the origins of developmental disease and congenital abnormalities. Current international efforts to examine gene function in the(More)
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised. These homozygous lethal mutants represent a potential treasure trove for the biomedical community. Developmental biologists could exploit them in their studies of tissue differentiation and(More)
The MouseBook (http://www.mousebook.org) databases and web portal provide access to information about mutant mouse lines held as live or cryopreserved stocks at MRC Harwell. The MouseBook portal integrates curated information from the MRC Harwell stock resource, and other Harwell databases, with information from external data resources to provide(More)
The realistic capabilities of image recognition today are unclear. There are some very effective techniques for image detection and image recognition, but there is still a semantic gap between the capabilities of humans and those of computers. This paper will give an overview to those techniques relating to image recognition and what computers can not yet(More)
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we combine low-coverage (0.15×) sequencing with a new method to impute the ancestral haplotype space in 1,887(More)
Creating a reliable computing environment from an unreliable infrastructure is a common challenge. Application-Level High Availability (HA) clustering addresses this problem by relocating and restarting applications when failures are detected. Current methods of determining the relocation target(s) of an application are rudimentary in that they do not take(More)
– The conceptual design of a 1200 MW thermal, 500 MW electrical, Traveling Wave Reactor (TWR) Plant has been completed with the objective of completing construction and startup by 2020. The reactor is a pool-type, sodium-cooled fast reactor and has been named TerraPower – 1 (TP-1). The TP-1 core will operate for over 40 years without refueling, but(More)