Tom Sidwell

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In 2011 Shoenfeld and Agmon-Levin proposed a new syndrome as a way of grouping together a range of emerging autoimmune diseases with possible adjuvant-associated causes, Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants (ASIA). At present, there is no evidence to suggest that ASIA syndrome is a viable explanation for unusual autoimmune diseases.(More)
Although the diverse functions served by the nuclear factor-κB (NF-κB) pathway in virtually all cell types are typically employed to deal with stress responses, NF-κB transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF-κB transcription factors control various aspects of thymic T-cell and myeloid(More)
Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.
After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription factor IRF4. Here, we show that tumor necrosis factor receptor superfamily (TNFRSF) signaling plays a(More)
volume 17 number 7 JulY 2016 nature immunology transgenic mouse model with GC B cell‒specific expression of a tamoxifen-inducible transgene encoding Cre recombinase that allows fate mapping of GC B cell progeny1. With this elegant model, the authors study the development of memory B cells and investigate the molecular events that occur during this process.(More)
Dear Ms Evans, The following document details a worrying discovery made regarding where Ms Dorey, current president of the Australian Vaccination Network (AVN), sourced some of her references used in her reply to Mr Ken McLeod's initial complaint. Ms Dorey begins: " Below are just a few of the hundreds of references to peer-reviewed studies which(More)
It should be noted that Ms Dorey’s claim that “Dr Wakefieldʼs study was only the first of many to indicate a very strong and, in some cases clinically verifiable connection between vaccination and the development of ASDs [autism spectrum disorders]” is incorrect; the Wakefield paper itself does not come to that conclusion. The discussion of the Wakefield(More)
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