Tom MacGillivray

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Diffusion tensor MR imaging (DT-MRI) yields information on early pathological changes in white matter of the ageing brain which may correlate with cognitive function. However, because individuals vary in their cognitive ability, a measurement of prior cognition from youth is required to understand fully the significance of MR imaging changes associated with(More)
This paper concerns the validation of automatic retinal image analysis (ARIA) algorithms. For reasons of space and consistency, we concentrate on the validation of algorithms processing color fundus camera images, currently the largest section of the ARIA literature. We sketch the context (imaging instruments and target tasks) of ARIA validation,(More)
Skeletal muscle volume is an important indicator of muscle function. Three-dimensional (3D) freehand ultrasound provides a noninvasive method for determining muscle volume and is acquired using a standard clinical ultrasound machine and an external tracking system to monitor transducer position. Eleven healthy volunteers were scanned with a 3D freehand(More)
PURPOSE To test the hypothesis that parameters of retinal vascular network geometry are significantly associated with cognition. METHODS Three hundred twenty-one community-dwelling, surviving participants in the Scottish Mental Survey of 1932 from the Lothian region of Scotland (Lothian Birth Cohort 1921; all born in 1921 and aged approximately 83 when(More)
PURPOSE To describe a revised formula for the estimation of retinal trunk arteriole widths from their respective arteriolar branch widths that improves the summarizing of retinal arteriolar diameters. METHODS A group of young, healthy individuals underwent retinal photography and arteriolar and venular branching points were identified. Vessel widths of(More)
Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR). 51 patients (63 (61–65) years, 80 % male) with known/suspected coronary artery disease(More)
Inflammation occurs in the acutely infarcted myocardium in order to remove necrotic cellular debris and allow tissue remodelling. Excessive inflammation may follow reperfusion therapy and can have detrimental effects on healing and left ventricular (LV) remodelling. With the aim of improving outcomes following acute myocardial infarction (MI), novel drugs(More)
BACKGROUND AND PURPOSE Lower birth weight is associated with increased risk of stroke, but little is known about the mechanism for this association or influence in addition to vascular risk factors. We investigated whether there was an association between birth parameters and imaging markers of white matter integrity in community-dwelling older people. (More)
BACKGROUND Abdominal aortic aneurysms are a major cause of death. Prediction of aneurysm expansion and rupture is challenging and currently relies on the simple measure of aneurysm diameter. Using MRI, we aimed to assess whether areas of cellular inflammation correlated with the rate of abdominal aortic aneurysm expansion. METHODS AND RESULTS Stable(More)
BACKGROUND & AIMS Sarcopenia and cachexia are characterized by infiltration of non-contractile tissue within muscle which influences area and volume measurements. We applied a statistical clustering (k-means) technique to magnetic resonance (MR) images of the quadriceps of young and elderly healthy women and women with cancer to objectively separate the(More)