Tom Leenhoven

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To determine the amount of occupational exposure to nitric oxide (NO) and nitrogen dioxide (NO2) during NO inhalational therapy. In a standard pediatric intensive care room, 800 ppm NO was delivered to a high-frequency oscillator and mixed with 100% O2 to obtain 20 ppm NO in the inspiratory gas flow. NO and NO2 concentrations in room air were measured using(More)
We hypothesized that during high-frequency oscillatory ventilation (HFOV), a reduction of peak-to-peak oscillatory pressure along the endotracheal tube is maximal when respiratory system compliance is maximal. We made a mathematical model of the endotracheal tube and the respiratory system of a neonate suffering from idiopathic respiratory distress syndrome(More)
INTRODUCTION The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a bench test we assessed the imposed WOB using 3100 A/3100 B SensorMedics high-frequency oscillatory ventilators. METHODS A(More)
To describe and validate a system for integrated measurement of ventilator settings and dependent physiological variables during high-frequency oscillatory ventilation (HFOV). A custom interface was built for data acquisition. Lung volume change was determined by respirator inductive plethysmography (RIP), modified to sampling rates of 140 Hz. Blood gas(More)
Objective. The objective of this study is to determine the accuracy andprecision of chemiluminescence and electrochemical nitric oxide (NO)measurements and accuracy of NO dosage with electronic mass flow controllers(MFC) versus rotameters during NO inhalational therapy. Methods. NO flow wasdelivered to a high frequency oscillator and mixed with ventilator(More)
The aim of this clinical study was to determine whether Doppler ultrasound can be used in newborn infants to assess the adequacy of palmar collateral circulation. Retrograde flow in the radial artery, distal to the site of manual occlusion of the vessel, was studied by Doppler technique. Forty-seven newborn infants, who underwent percutaneous radial artery(More)
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