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RATIONALE Two forms of the IFN-gamma release assay (IFNGRA) to detect tuberculosis infection are available, but neither has been evaluated in comparable HIV-infected and uninfected persons in a high tuberculosis incidence environment. OBJECTIVE To compare the ability of the T-SPOT.TB (Oxford Immunotec, Abingdon, UK), QuantiFERON-TB Gold (Cellestis,(More)
BACKGROUND The diagnosis of latent Mycobacterium tuberculosis (MTB) infection with a tuberculin skin test (TST) in children is complicated by the potential influence of prior exposure to Bacille Calmette Geurin (BCG) vaccination or environmental mycobacteria. A whole blood assay has recently been developed to quantitatively measure interferon gamma(More)
BACKGROUND There are limited data comparing the performance of the two commercially available interferon gamma (IFN-gamma) release assays (IGRAs) for the diagnosis of tuberculosis (TB) in children. We compared QuantiFERON-TB gold In Tube (QFT-IT), T-SPOT.TB and the tuberculin skin test (TST) in children at risk for latent TB infection or TB disease. (More)
The identification of improved diagnostic tests for tuberculosis has been identified as a global research priority. Over the past decade, there has been renewed interest in the development and validation of novel diagnostic tools for pulmonary tuberculosis that are applicable to resource-poor settings. These techniques are aimed primarily at improving(More)
BACKGROUND Recent interest has focused on the potential use of serial interferon gamma (IFN-gamma) release assay (IGRA) measurements to assess the response to anti-tuberculous (TB) treatment. The kinetics of IFN-gamma responses to Mycobacterium tuberculosis (MTB) antigens in HIV-infected children during treatment have not however been previously(More)
BCG vaccine is one of the most commonly-administered vaccines worldwide. Studies suggest the protective efficacy of BCG against TB is better for children than for adults. One potential explanation is that BCG induces a better protective immune response in children. Twenty six children and adults were immunised with BCG. The proportion of(More)
OBJECTIVE The primary aim of this study was to determine age-stratified rates of co-existing bacterial meningitis in children with urinary tract infection (UTI). The secondary aims of this study were to determine the causative pathogens of UTI, and the clinical features and outcome of children with co-existing meningitis. METHODS Analysis of data(More)
The study reported by Lucas et al 1 is a valuable addition to recent publications that have compared the performance of commercial interferon-g release assays (IGRAs) with that of the tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection (LTBI) in high-risk children. 2 3 However, we believe that the principal conclusions are not(More)
BACKGROUND There are limited data on the epidemiology, diagnosis and optimal management of nontuberculous mycobacterial (NTM) disease in children. METHODS Retrospective cohort study of NTM cases over a 10-year-period at a tertiary referral hospital in Australia. RESULTS A total of 140 children with NTM disease, including 107 with lymphadenitis and 25(More)
We describe the development and evaluation of a web-based, paediatric infectious diseases (PID) journal club (JC). A coordinated roster with monthly submissions from 11 clinical sites has increased knowledge-sharing, member-engagement and opportunities for trainees to be mentored in critical appraisal writing. The JC is now in its third year with ongoing(More)