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Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate patient management and antibiotic misuse. Bacterial-induced host proteins such as procalcitonin, C-reactive protein (CRP), and Interleukin-6, are routinely used to support diagnosis of infection. However, their performance is negatively affected by inter-patient(More)
There have been impressive surgical, radiotherapeutic, and chemotherapeutic advances in treating cancer. However, the outlook for patients with malignant brain tumors is still dismal. Gene therapy offers hope of replacing defective genes, amplifying the immune response to cancer, and sensitizing tumor cells to systemic therapies (suicide gene therapy). The(More)
Ciliopathies are developmental disorders that arise due to defects in cilia biogenesis and function, and affect various sensory systems including the auditory system. Involvement of multiple syndromic ciliopathy genes, whose protein products are thought to function as macromolecular complexes in both cilia and basal bodies, implicate dynamic regulation of(More)
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