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OBJECTIVE To establish the predictive accuracy of the Framingham risk score for coronary heart disease in a representative British population. DESIGN Prospective cohort study. SETTING 24 towns in the United Kingdom. PARTICIPANTS 6643 British men aged 40-59 years and free from cardiovascular disease at entry into the British regional heart study. (More)
BACKGROUND Checklists for peer review aim to guide referees when assessing the quality of papers, but little evidence exists on the extent to which referees agree when evaluating the same paper. The aim of this study was to investigate agreement on dimensions of a checklist between two referees when evaluating abstracts submitted for a primary care(More)
Increasing duration of tamoxifen therapy improves survival in women with breast cancer but the impact of adherence to tamoxifen on mortality is unclear. This study investigated whether women prescribed tamoxifen after surgery for breast cancer adhered to their prescription and whether adherence influenced survival. A retrospective cohort study of all women(More)
OBJECTIVES To compare the prevalence of use of potentially inappropriate medicines (PIMs) between older patients living in their own homes versus those living in nursing or residential homes, and to test the association between exposure to PIMs and mortality. DESIGN Cohort study stratified by place of residence. SETTING Tayside, Scotland. PARTICIPANTS(More)
BACKGROUND Evidence-based advice on alcohol consumption is required for pregnant women and women planning a pregnancy. Our aim was to investigate the prevalence, predictors and perinatal outcomes associated with peri-conceptional alcohol consumption. METHODS A cohort study of 61,241 women who booked for antenatal care and delivered in a large urban(More)
BACKGROUND Spontaneous intracerebral hemorrhage (SICH) has a high morbidity and mortality and places a huge significant economic burden on health care and social services. The role of surgery is still controversial as evidenced by wide variation internationally in management of SICH. Traditional surgery for SICH involved open craniotomy with hematoma(More)
We sought to estimate the prevalence of potentially inappropriate prescribing (PIP) in the Northern Ireland (NI) population aged ≥70 years, to investigate factors associated with PIP and to calculate total gross cost of PIP. A retrospective cross-sectional population study was carried out in those aged ≥70 years in 2009/2010 who were in primary care in NI.(More)
BACKGROUND Lack of adherence to blood pressure-lowering medication is a major reason for poor control of hypertension worldwide. The objective of this study was to determine the effectiveness of interventions to increase adherence to blood pressure-lowering medication. METHODS We performed a systematic review of randomized controlled trials and searched(More)
OBJECTIVE To assess predictors of mortality in a population of people prescribed methadone. DESIGN Retrospective cohort study. SETTING Geographically defined population in Tayside, Scotland. PARTICIPANTS 2378 people prescribed and dispensed liquid methadone between January 1993 and February 2004. MAIN OUTCOME MEASURES All cause mortality (primary(More)
BACKGROUND The Timed Up and Go test (TUG) is a commonly used screening tool to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall predictive value of the TUG in community-dwelling older adults. METHODS A literature search was performed to identify all studies that(More)