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A compiler for VLIW and superscalar processors must expose sufficient instruction-level parallelism (ILP) to effectively utilize the parallel hardware. However, ILP within basic blocks is extremely limited for control-intensive programs. We have developed a set of techniques for exploiting ILP across basic block boundaries. These techniques are based on a(More)
Code optimization and scheduling for superscalar and superpipelined processors often increase the register requirement of programs. For existing instruction sets with a small to moderate number of registers, this increased register requirement can be a factor that limits the effectivess of the compiler. In this paper, we introduce a new architectural method(More)
A compiler for VLIW and superscalar processors must expose suucient instruction-level parallelism ILP to eeectively utilize the parallel hardware. However, ILP within basic blocks is extremely limited for control-intensive programs. We h a v e developed a set of techniques for exploiting ILP across basic block boundaries. These techniques are based on a(More)
The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 early-stage and 14 advanced-stage cancers).(More)
The effect of peptide YY (PYY) on active electrolyte transport in rat colon was studied under short-circuited conditions. PYY (10(-6) M) decreased the basal short-circuit current (Isc) in both the distal and proximal segments of the colon. The decrease in Isc induced by PYY in the distal colon was about 3 times larger than that in the proximal colon. The(More)
By exploiting fine grain parallelism, superscalar processors can potentially increase the performance of future supercomputers. However, supercomputers typically have a long access delay to their first level memory which can severely restrict the performance of superscalar processors. Compilers attempt to move load instructions far enough ahead to hide this(More)
Compilers for superscalar and VLIW processors must expose suucient instruction-level parallelism in order to achieve high performance. Compile-time code transformations which expose instruction-level parallelism typically take into account the constraints imposed by all execution scenarios in the program. However, there are additional opportunities to(More)
Moderate size register les can limit the performance of loop unrolling on multiple issue processors. With current scheduling heuristics, a breadth-rst scheduling of iterations occurs, increasing register pressure and generating excessive spill code. A heuristic is proposed that causes a more depth-rst scheduling of unrolled iterations. This heuristic(More)
The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w, were analysed in human colorectal(More)
In synthetic studies on the chemical modification of the nucleoside antibiotic bredinin, two new derivatives, 5-carbamoyl-1H-imidazol-4-yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4-yl piperonylate, were found to possess a potent antitumor activity in several experimental tumor systems, even though bredinin itself shows only in vitro cytotoxicity(More)