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The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the wholeExpand
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Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway
The activation process of secretory or membrane-bound zinc enzymes is thought to be a highly coordinated process involving zinc transport, trafficking, transfer and coordination. We have previouslyExpand
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The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.
Secretory and membrane-bound zinc-requiring enzymes are thought to be activated by binding zinc in the early secretory pathway. One such enzyme, tissue-non-specific alkaline phosphatase (TNAP), isExpand
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Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters*
Zinc-requiring ectoenzymes, including both secreted and membrane-bound enzymes, are considered to capture zinc in their active site for their activation in the early secretory pathway. This idea hasExpand
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Molecular Mechanisms for Protection of Hepatocytes against Bile Salt Cytotoxicity.
Biliary lipids consist mainly of bile salts, phospholipids and cholesterol, which form mixed micelles and vesicles. Bile salts play various physiological roles but have damaging effects on cellExpand
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Zinc Transport Proteins and Zinc Signaling
There is an increasing body of evidence indicating that zinc transport proteins play crucial roles in a variety of biological events. The Zrt, Irt-like protein/solute carrier family 39 (ZIP/SLC39A)Expand
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Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation
Numerous zinc ectoenzymes are metalated by zinc and activated in the compartments of the early secretory pathway before reaching their destination. Zn transporter (ZNT) proteins located in theseExpand
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Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux.
Hydrophilic bile salts, ursodeoxycholate and hyodeoxycholate, have choleretic effects. ABCB4, a member of the ABC transporter family, is essential for the secretion of phospholipids from hepatocytesExpand
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Protocols for Enzymatic Fluorometric Assays to Quantify Phospholipid Classes
Phospholipids, consisting of a hydrophilic head group and two hydrophobic acyl chains, are essential for the structures of cell membranes, plasma lipoproteins, biliary mixed micelles, pulmonaryExpand
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Enzymatic fluorometric assays for quantifying all major phospholipid classes in cells and intracellular organelles
Cell membrane phospholipids regulate various biological functions. We previously reported enzymatic fluorometric methods for quantifying phosphatidic acid, phosphatidylcholine,Expand
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