Tokihito Hirose

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PURPOSE To determine the spectrum of ABCR mutations associated with Stargardt macular degeneration and cone-rod degeneration (CRD). METHODS One hundred eighteen unrelated patients with recessive Stargardt macular degeneration and eight with recessive CRD were screened for mutations in ABCR (ABCA4) by single-strand conformation polymorphism analysis.(More)
Retinal functions were analyzed psychophysically and electrophysiologically in 73 patients (146 eyes) with Stargardt's disease/fundus flavimaculatus. Patients were classified into types 1, 2, 3, and 4; patients with type 3 were subdivided into 3E and 3L (early and late onset of initial symptoms). Most had visual acuity (VA) of 20/200 or greater at initial(More)
BACKGROUND Changes in the retina caused by diabetes may lead to visual impairment in dim light, even with good visual acuity and visual fields. To evaluate the visual abnormalities preceding the retinopathy in patients with type 1 diabetes mellitus (DM), we applied electrophysiological methods. METHODS The visual evoked responses were recorded with(More)
BACKGROUND We compared the visual acuities obtained with preferential looking (PL), the most widely used method of pediatric vision assessment, with those obtained with the spatial frequency sweep pattern-reversal visual evoked response (SPVER). METHODS Eighty patients (ages 1.5 months to 12 years) with various ocular pathologies participated in this(More)
The effects of the sizes of the stimulus field and of an artificially created central scotoma on simultaneously recorded pattern-reversal electroretinogram (P-ERG) and pattern-reversal visual-evoked response (P-VER) were investigated. With an increase in the stimulus field from 4 degrees X 4 degrees to 12 degrees X 12 degrees, the amplitude of the P-ERG(More)
The electroretinogram (ERG), especially the b/a wave ratio, is considered a good indicator of retinal ischaemia in central retinal vein obstruction (CRVO). Seven CRVO patients who showed b/a wave ratio improvement from < 1.0 [negative type (-) ERG] to > or = 1.0 and one from 1.07 to 1.53 were studied. Three mechanisms of change were observed: firstly, the(More)
BACKGROUND We compared the vision objectively assessed by spatial frequency sweep pattern-reversal visual-evoked response (SPVER) with the Snellen acuity in patients. METHODS SPVER acuity and Snellen acuity were measured in 100 patients with various ocular pathologies, including macular diseases, diffuse retinal degeneration, optic nerve diseases,(More)
We studied the effects of unequal or unbalanced visual inputs on the binocular system of normal subjects by measuring the amplitudes of the binocularly and the monocularly recorded VER and determining the value of binocular summation. The stimuli used were patterns that were either fused or not fused, of unequal luminosity and of unequal image size. When(More)
Electroretinograms (ERG) and electro-oculograms (EOG) were studied in 88 eyes of 44 male patients with X-linked recessive retinoschisis. Differences of fundus appearance, ERG, and EOG between the eyes of each patient were analyzed. Fundus abnormalities were symmetrical in 77.3% of the cases. The amplitude of the ERG a-wave was normal in 26.1% and was(More)
Because the pattern-reversal visual evoked response (PVER) reflects the central retinal function, PVER results generally agree with those of psychophysical tests. The visual acuities (VAs) calculated from PVER recordings and Snellen acuity (SA) measurements were compared in 500 eyes (261 patients; ages 8 to 88 years; mean, 44.5 years). The best-corrected VA(More)