Toine ten Broeke

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The importance of conventional dendritic cells (cDCs) in the processing and presentation of antigen is well established, but the contribution of plasmacytoid dendritic cells (pDCs) to these processes, and hence to T cell immunity, remains unclear. Here we showed that unlike cDCs, pDCs continued to synthesize major histocompatibility complex (MHC) class II(More)
Efficacy of anticancer monoclonal antibodies (mAb) is limited by the exhaustion of effector mechanisms. IgG mAbs mediate cellular effector functions through FcgRs expressed on effector cells. IgAmAbs can also induce efficient tumor killing both in vitro and in vivo. IgA mAbs recruit FcaRI-expressing effector cells and therefore initiate different effector(More)
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