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From the First World War onwards anti-cancer organizations in Europe attempted to spread the message of "Do Not Delay": cancer is curable, if and when early diagnosed. This article reports on a systematic study of sources on cancer health education from the medical and public domains in the Netherlands between 1910 and 1950. Dutch cancer specialists were(More)
BACKGROUND In 2003-2004 and 2007-2008, the regulatory banning of SSRI use in pediatrics and young adults due to concerns regarding suicidality risk coincided with negative media coverage. SSRI use trends were analyzed from 2000-2010 in the Netherlands (NL) and the UK, and whether trend changes might be associated with media coverage of regulatory warnings.(More)
OBJECTIVE In the Netherlands, in 2007, the national newborn screening program was expanded from 3 to 17 disorders that met the World Health Organization's Wilson and Jungner screening criteria, especially regarding treatability. The decision of whether to add diseases to the program is generally based on experts' advice, whereas the opinion of those whom it(More)
The possibility of gene doping, defined as the transfer of nucleic acid sequences and/or the use of normal or genetically modified cells to enhance sport performance, is a real concern in sports medicine. The abuse of knowledge and techniques gained in the area of gene therapy is a form of doping, and is prohibited for competitive athletes. As yet there is(More)
Concerns emanating from the medical community about the safety and efficacy of biosimilars indicate an increasing distrust of the outcome of the drug regulatory process. To illustrate this, we analysed the creation of the European biosimilar regulatory framework, specifically focussing on the guidelines outlining approval criteria for biosimilar(More)
Recent decades have witnessed increasing possibilities for genetic testing and screening. In clinical genetics, the doctor’s office defined a secluded space for discussion of sensitive reproductive options in cases of elevated risk for genetic disorders in individuals or their offspring. When prenatal screening for all pregnant women became conceivable, the(More)
The availability of digitized collections of historical data, such as newspapers, increases every day. With that, so does the wish for historians to explore these collections. Methods that are traditionally used to examine a collection do not scale up to today's collection sizes. We propose a method that combines text mining with exploratory search to(More)
The availability of digitized collections of historical data, such as newspapers, increases every day. With that, so does the wish for historians to explore these collections. Methods that are traditionally used to examine a collection do not scale up to today's collection sizes. We propose a method that combines text mining with exploratory search to(More)