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The detailed process of how dystrophic muscles are replaced by fibrotic tissues is unknown. In the present study, the immunolocalization and mRNA expression of connective tissue growth factor (CTGF) in muscles from normal and dystrophic human muscles were examined with the goal of elucidating the pathophysiological function of CTGF in muscular dystrophy.(More)
By cutting the brachial plexus at a few levels on the side stimulated, it was verified that the first far-field component of SEPs with forepaw reference recording is generated in the brachial plexus in the cat. Incidentally, a reversal of the polarity of the earliest portion of the first component was observed with abduction of the upper arm to a high(More)
Recently, we cloned a messenger RNA (mRNA) predominantly expressed in chondrocytes from a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8, by differential display PCR and found that its gene, named hcs24, was identical with that of connective tissue growth factor (CTGF). Here we investigated CTGF/Hcs24 function in the chondrocytic cell line(More)
The origin and course of the posterior femoral cutaneous nerve were observed macroscopically in 38 Japanese adult cadavers which were dissected in the University of Hokkaido, Faculty of Medicine during the years 1971/72 and the results obtained were compared with those from some other mammals (rat, rabbit, dog and cat) and a number of bibliographical(More)
Short latency SEPs recorded in hand-scalp, ear-scalp and upper neck-scalp leads with stimulation of the median nerve were examined in 27 normal subjects and in 11 selected patients with unilateral complete loss of position sense in order to provide information concerning the generator sources of these potentials. Evidences obtained from both normal subjects(More)
The concept that action potentials recorded by fluid electrodes may be generated at the point of the entrance to and the exit from the partition and that the action potential recorded by the fluid electrodes with a number of partitions between them may be equal to the algebraic sum of the action potentials recorded by the electrodes adjacent to each(More)
The initial positive component of the scalp-recorded somatosensory evoked potential to median nerve stimulation was studied in 12 patients with sensory impairment for all modalities of the unilateral extremities due to lesions at or above or below the thalamic level, taking the potentials obtained from eight normal subjects as control. In normal subjects,(More)
Connective tissue growth factor (CTGF) is an immediate early growth-responsive gene but its distribution and significance in the central nervous system (CNS) are unknown. We investigated the distribution of CTGF-like immunoreactivity (CTGF-IR) in the rat CNS using a specific antiserum against CTGF oligopeptide. The majority of CTGF-IR was observed in(More)
Using bullfrog's sciatic-peroneal nerve, action potentials recorded by fluid electrodes were studied under a variety of conditions. Action potential obtained by the adjacent fluid electrodes was diphasic, and its amplitude was directly proportional to the impedance between the fluid electrodes. The number of peaks of action potential was equal to that of(More)