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Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the(More)
Glial cytoplasmic inclusions (GCI) are the hallmark of multiple system atrophy (MSA), a rare movement disorder frequently associated with autonomic dysfunction. In this study of 21 cases of MSA, GCI were consistently immunoreactive for alpha-synuclein and double-immunostained for ubiquitin and oligodendroglial markers, but not glial fibrillary acidic(More)
1 Abstract The research outlined in this paper marks an initial global cooperative effort between visualization and collaboration researchers to build a persistent virtual visualization facility linked by ultra-high-speed optical networks. The goal is to enable the comprehensive and synergistic research and development of the necessary hardware, software(More)
A layered architecture for advanced collaborative environments has been developed to map the definition of a collaboration task from the requirements needed to accomplish the task, to the collaboration services that can be used to satisfy those needs, and to the technologies on which the services can be delivered. The architecture takes into account the(More)
Aging is associated with conduit artery stiffening that is a risk factor for and can precede hypertension and ventricular dysfunction. Increases in mitochondria DNA (mtDNA) frequency have been correlated with aging. Mice with a mutation in the encoding domain (D257A) of a proof-reading deficient version of mtDNA polymerase-γ (POLG) have musculoskeletal(More)
  • Jason Leigh, Luc Renambot, Andrew Johnson, Byung-Il, Brent Jeong, Ratko Jagodic +29 others
  • 2010
1 Abstract The research outlined in this paper marks an initial global cooperative effort between visualization and collaboration researchers to build a persistent virtual visualization facility linked by ultra-high-speed optical networks. The goal is to enable the joint research and development of the necessary hardware, software and interaction techniques(More)
The domain of Advanced Collaborative Environments (ACE) is rapidly evolving. Advanced computation, display, storage, sensor, interaction, and networking technologies provide us with a wealth of mechanisms with which to explore complex scientific phenomena. This is especially true in the academic research community where large-scale computational consortia(More)
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