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Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the(More)
Selective modification of the tetrahydrobiopterin levels in cultured chromaffin cells were followed by changes in the rate of tyrosine hydroxylation. Addition of sepiapterin, an intermediate on the salvage pathway for tetrahydrobiopterin synthesis, rapidly increased intracellular levels of tetrahydrobiopterin and elevated the rate of tyrosine hydroxylation(More)
1 Abstract The research outlined in this paper marks an initial global cooperative effort between visualization and collaboration researchers to build a persistent virtual visualization facility linked by ultra-high-speed optical networks. The goal is to enable the comprehensive and synergistic research and development of the necessary hardware, software(More)
A layered architecture for advanced collaborative environments has been developed to map the definition of a collaboration task from the requirements needed, to accomplish the task to the collaboration services that can be used to satisfy those needs, and to the technologies on which the services can be delivered. The architecture takes into account the(More)
The in vitro destruction of tumor cells by specifically sensitized mouse lymphocytes was inhibited by adenosine; this inhibition was markedly potentiated by the presence of an inhibitor of adenosine deaminase. The inhibition of cytolysis by adenosine was accompanied by a rapid elevation in lymphocytic adenosine 3',5'-monophosphate (cyclic AMP)(More)
1 Abstract The research outlined in this paper marks an initial global cooperative effort between visualization and collaboration researchers to build a persistent virtual visualization facility linked by ultra-high-speed optical networks. The goal is to enable the joint research and development of the necessary hardware, software and interaction techniques(More)
The domain of Advanced Collaborative Environments (ACE) is rapidly evolving. Advanced computation, display, storage, sensor, interaction, and networking technologies provide us with a wealth of mechanisms with which to explore complex scientific phenomena. This is especially true in the academic research community where large-scale computational consortia(More)
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