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  • Mohab M. Ibrahim, Hongfeng Deng, +8 authors T. Philip Malan
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2003 (First Publication: 13 August 2003)
  • We designed AM1241, a selective CB2 cannabinoid receptor agonist, and used it to test the hypothesis that CB2 receptor activation would reverse the sensory hypersensitivity observed in neuropathicExpand
  • Matthew N. Rasband, Eunice W. Park, Todd W. Vanderah, Josephine Lai, Frank Porreca, James S. Trimmer
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 6 November 2001)
  • Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model of neuropathic pain leads to striking reductionsExpand
  • Shannon E Burgess, Luis R. Gardell, +4 authors Frank Porreca
  • Medicine, Biology
  • The Journal of Neuroscience
  • 2002 (First Publication: 15 June 2002)
  • Although injury-induced afferent discharge declines significantly over time, experimental neuropathic pain persists unchanged for long periods. These observations suggest that processes that initiateExpand
  • Narender r. Gavva, Rami Tamir, +13 authors James J. S. Treanor
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2005 (First Publication: 1 April 2005)
  • The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel expressed by peripheral sensory neurons. TRPV1 antagonists produce antihyperalgesic effects in animal modelsExpand
  • Mohab M. Ibrahim, Frank Porreca, +8 authors T. Philip Malan
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 22 February 2005)
  • CB(2) cannabinoid receptor-selective agonists are promising candidates for the treatment of pain. CB(2) receptor activation inhibits acute, inflammatory, and neuropathic pain responses but does notExpand
  • Todd W. Vanderah, Naoki Suenaga, Michael H. Ossipov, T. Philip Malan, J. Lai, Frank Porreca
  • Medicine
  • The Journal of Neuroscience
  • 2001 (First Publication: 1 January 2001)
  • Many clinical case reports have suggested that sustained opioid exposure can elicit unexpected, paradoxical pain. Here, we explore the possibility that (1) opioid-induced pain results from tonicExpand
  • Stevens S. Negus, Todd W. Vanderah, Michael Richard Brandt, Edward J. Bilsky, Lino Becerra, David Borsook
  • Medicine
  • Journal of Pharmacology and Experimental…
  • 2006 (First Publication: 1 November 2006)
  • In analgesic drug development, preclinical procedures are widely used to assess drug effects on pain-related behaviors. These procedures share two principal components: 1) a manipulation intended toExpand