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  • Aravind Subramanian, Pablo Tamayo, +8 authors Jill P. Mesirov
  • Computer Science, Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 30 September 2005)
  • Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe aContinue Reading
  • Pablo Tamayo, D. M. Slonim, +5 authors Todd R. Golub
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Publication: 16 March 1999)
  • Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The challenge now is to interpret such massive data sets. The first step is toContinue Reading
  • Jean-Philippe Brunet, Pablo Tamayo, Todd R. Golub, Jill P. Mesirov
  • Computer Science, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2004 (First Publication: 11 March 2004)
  • We describe here the use of nonnegative matrix factorization (NMF), an algorithm based on decomposition by parts that can reduce the dimension of expression data from thousands of genes to a handfulContinue Reading