Todd R. Mitchell

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This communication describes a young man with chronic glomerular nephritis whose serum contained cold antibodies directed against both red cells and lymphocytes. A renal biopsy revealed unusual histological features including extensive deposits of IgM and complement. Although abnormal immune responses are not uncommon in chronic renal failure, it is(More)
A case of chronic myelomonocytic leukemia is described in which the patient presented on two separate occasions with peripheral corneal infiltrates. On the first occasion the white blood cell count was high, and on the second the patient's leukemia had relapsed. Resolution of the eye signs occurred following local treatment and systemic chemotherapy.
STUDY OBJECTIVE To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain. DESIGN A prospective, randomized, single-dose, double-blind study. SETTING ED of a university hospital and an affiliated county hospital.(More)
Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on(More)
Iron is a critical component of the CNS that must be tightly regulated; too little iron can result in energy insufficiency and too much iron can result in oxidative stress. The intracellular iron storage protein ferritin is central to the regulation of iron. In this study, we determined the neurochemical profile of brains of animals deficient in heavy-chain(More)