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Functional MRI is an imaging technique that provides high resolution information about brain blood ow and oxygenation. This information is used to deduce which regions of the brain are activated by various stimuli. Analysis of functional MRI data is complicated by the low signal-to-noise ratios typically encountered. Two diierent wavelet-based noise removal(More)
where sxβ is the sample variance of x T 1 β, . . . ,x T nβ, representing variance explained by the model, and R2 is the specified value (0.1 or 0.5). The left side of (A2) is similar to what Tibshirani and Knight (1999) called the “theoretical R2,” and has the interpretation that for responses generated according to (A1), (A2), the coefficient of(More)
BACKGROUND Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent. This could reflect analytic heterogeneity, such as use of region-wise cortical thickness based on the Freesurfer Desikan-Killiany (DK) atlas or surface-based morphometry (SBM). The Freesurfer Destrieux (DS) atlas (more, smaller regions)(More)
BACKGROUND Major depressive disorder (MDD) and anxiety disorders are highly co-morbid. Research has shown conflicting evidence for white matter alteration and amygdala volume reduction in mood and anxiety disorders. To date, no studies have examined differences in structural connectivity between anxious depressed and non-anxious depressed individuals. This(More)
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