Learn More
Previously, recombinant erythropoietin (rEpo) was shown to increase the number and size of megakaryocytic colonies in vitro, and in vivo it elevates the number of megakaryocytes in mouse spleens. To test the hypothesis that rEpo would stimulate platelet production in mice, both normal mice and mice in rebound-thrombocytosis were injected with rEpo and the(More)
The existence of thrombopoietin, a hormone that controls blood platelet production, was proposed almost 30 years ago, but it has been only during the past 10-15 years that sufficient knowledge was obtained to establish that this humoral factor is a major in vivo controlling factor of thrombocytopoiesis. This concise review attempts to summarize the(More)
Human embryonic kidney cells were maintained in culture in a medium containing lactalbumin hydrolysate for 5 to 6 weeks and the supernatant fluid tested for thrombopoietin content. Thrombopoietin was determined by a bioassay procedure which utilized mice that were in rebound thrombocytosis. The results indicate that the medium from kidney cells in culture(More)