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A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma.
- W. Wilmer, C. Dixon, L. Lu, T. Hilbelink, B. Rovin
- Biology, Medicine
- Biochemical and biophysical research…
- 16 February 2001
The mitogen-activated protein (MAP) kinases mediate the response of renal glomerular mesangial cells to a variety of physiologic and pathologic stimuli. This investigation examines the effect of the… Expand
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
BACKGROUND Proliferation of intrinsic glomerular cells is a common response to renal injury. Acutely, proliferation may be beneficial, but sustained glomerular hypercellularity after injury is… Expand