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transferred without further notice and the accepted version may then be posted by the publisher. Abstract Active measurements, examine the capabilities of networks and the internet. Through the network analysis infrastructure (NAI), these measurements can provide useful data for network analysis. The National Laboratory for Applied Network Research (NLANR)(More)
A high-throughput screen against human DGAT-1 led to the identification of a core structure that was subsequently optimized to afford the potent, selective, and orally bioavailable compound 14. Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute(More)
DomainKeys Identified Mail (DKIM) Service Overview draft-ietf-dkim-overview-02 Status of this Memo By submitting this Internet-Draft, each author represents that any applicable patent or other IPR claims of which he or she is aware have been or will be disclosed, and any of which he or she becomes aware will be disclosed, in accordance with Section 6 of BCP(More)
— As networks grow faster everyday, network measurement and analysis becomes more important. This paper gives a brief description of the High Performance Wireless Research and Education Network (HPWREN) Measurement and Analysis Infrastructure. We then discuss three case studies in which measurements provided a key component in determining specific problems(More)
Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the lead scaffold resulted in the identification of compounds exhibiting low-nanomolar potency and(More)
A structurally novel acetyl-CoA carboxylase (ACC) inhibitor is identified from high-throughput screening. A preliminary structure-activity relationship study led to the discovery of potent dual ACC1/ACC2 and ACC2 selective inhibitors against human recombinant ACC1 and ACC2. Selective ACC2 inhibitors exhibited IC50<20 nM and >1000-fold selectivity against(More)
A preliminary safety evaluation of ACC2 inhibitor 1-(S) revealed serious neurological and cardiovascular liabilities of this chemotype. A systematic structure-toxicity relationship study identified the alkyne linker as the key motif responsible for these adverse effects. Toxicogenomic studies in rats showed that 1-(R) and 1-(S) induced gene expression(More)
Delivering small interfering RNA (siRNA) to tumors is the major technical hurdle that prevents the advancement of siRNA-based cancer therapy. One of the difficulties associated with the development of clinically relevant delivery systems is the lack of reliable tools for monitoring siRNA delivery to tumors in vivo. We describe here a novel, positive-readout(More)
9 : Prameworks are key components for achieving reuse of analysis, design and implementation in object-oriented technology. However, developing high-quality frameworks is a challenging task for most organizations. The purpose of this workshop was to help identify the key ingredients for developing, supporting, and maintaining successful frameworks. The(More)
As sensor networks become denser and more widely deployed, the potential develops for interconnecting these networks to combine datasets, share technological solutions, and to conduct cross-disciplinary research and monitoring operations that rely on several signal domains simultaneously. To that end, the real-time observatories, applications and data(More)