Todd H. Rider

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We report the use of genetically engineered cells in a pathogen identification sensor. This sensor uses B lymphocytes that have been engineered to emit light within seconds of exposure to specific bacteria and viruses. We demonstrated rapid screening of relevant samples and identification of a variety of pathogens at very low levels. Because of its speed,(More)
Currently there are relatively few antiviral therapeutics, and most which do exist are highly pathogen-specific or have other disadvantages. We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces apoptosis in cells containing viral dsRNA, rapidly killing(More)
The growing threat of biological agents, new diseases, and food-borne pathogens has created an increasing need for rapid and sensitive detection before the target population becomes infected. The incident of the anthrax letters in October 2001, the emergence of Severe Acute Respiratory Syndrome (SARS) and the West Nile virus, and repeated occurrences of(More)
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