Todd D Otteson

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OBJECTIVES To investigate interventions used in treating obstructive sleep apnea in neonates and infants and to report their efficacies. DESIGN Retrospective medical record review. SETTING Tertiary care children's hospital. PATIENTS Neonates and infants aged 0 to 12 months at the time of obstructive sleep apnea diagnosis by polysomnography. MAIN(More)
OBJECTIVE To determine the prevalence of hoarseness in the cleft palate population. DESIGN Retrospective chart review from a tertiary pediatric hospital's craniofacial clinic. PATIENTS Nonsyndromic patients with cleft palate who had undergone cleft palate repair were eligible for inclusion. Patients were excluded if they had previously undergone a(More)
OBJECTIVES To determine whether (1) inflammatory mediators IL-1beta (interleukin 1beta) and prostaglandin E2 (PGE2) in mucosal secretions correlate with subglottic mucosal injury; and (2) mucosal fibroblasts contribute to PGE2 production during mucosal healing. DESIGN The subglottic mucosa in rabbits was wounded by means of varied carbon dioxide laser(More)
OBJECTIVE To investigate the association between mucosal fibroblast activity and subglottic stenosis (SGS) development. DESIGN Prospective study of an animal model of SGS. SETTING Academic research laboratory. SUBJECTS New Zealand white rabbits were assigned to either the cricothyroidotomy and carbon dioxide laser injury group or the cricothyroidotomy(More)
OBJECTIVES/HYPOTHESIS To characterize the activation of cyclooxygenase (COX)-2/prostaglandin (PG) E2 signaling during airway mucosal repair and its subsequent role during the wound healing process. STUDY DESIGN Prospective animal study. METHODS The subglottis was approached via cricothyroidotomy. Sham airways were closed, and wounded airways were(More)
OBJECTIVE To conduct an endoscopic and histologic analysis of the subglottic effects of various carbon dioxide laser-induced injuries in the rabbit model. DESIGN Animals were assigned to either a control (cricothyroidotomy only) group or 4 (cricothyroidotomy and posterior subglottic laser) groups that were injured using varying systematically controlled(More)
OBJECTIVE To investigate the repair process following carbon dioxide laser injury to the upper airway mucosa (UAM) during the development of chronic subglottic stenosis (SGS). DESIGN Animals were assigned to either sham control (cricothyroidotomy only) or injured (cricothyroidotomy and posterior subglottic laser) groups using various carbon dioxide laser(More)
The clinical triad of micrognathia (small mandible), glossoptosis (backward, downward displacement of the tongue), and airway obstruction defines the Pierre Robin sequence (PRS). Airway obstruction and respiratory distress are clinical hallmarks. Patients may present with stridor, retractions, and cyanosis. Severe obstruction results in feeding difficulty,(More)
OBJECTIVES/HYPOTHESIS To investigate the prevalence of eustachian tube dysfunction (ETD) in infants with obstructive sleep apnea (OSA). STUDY DESIGN Retrospective medical record review of infants (3-24 months old) diagnosed with OSA and ETD. METHODS There were 94 infants diagnosed with OSA by polysomnography and ETD as determined by performance of(More)