Tobias Weigel

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Surgical implantation of a biomaterial triggers foreign-body-induced fibrous encapsulation. Two major mechanisms of this complex physiological process are (I) chemotaxis of fibroblasts from surrounding tissue to the implant region, followed by (II) tissue remodeling. As an alternative to animal studies, we here propose a process-aligned in vitro test(More)
Despite growing effort to advance materials towards a low fibrotic progression, all implants elicit adverse tissue responses. Pre-clinical biomaterial assessment relies on animals testing, which can be complemented by in vitro tests to address the Russell and Burch's 3R aspect of reducing animal burden. However, a poor correlation between in vitro and in(More)
Cartilage degeneration is the major cause of chronic pain, lost mobility, and reduced quality of life for over estimated 150 million osteoarthritis sufferers worldwide. Despite intensive research, none of the available therapies can restore the hyaline cartilage surface beyond just fibrous repair. To overcome these limitations, numerous cell-based(More)
Several scientific communities relying on e-science infrastructures are in need of persistent identifiers for data and contextual information. In this article, we present a framework for persistent identification that fundamentally supports context information. It is installed as a number of low-level requirements and abstract data type descriptions,(More)
Ontologies need to introduce some primitive symbols used for the definition of more complex ones. These primitive symbols have no formal definitions in the ontology, and as ontologies usually are incomplete axiomatizations, the semantics of the primitives remain ambiguous (Guarino 1998). This shifts the problem of semantic interoperability to the problem of(More)
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