Tobias Schwarz

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The generation of new neurons from neural stem cells in the adult hippocampal dentate gyrus contributes to learning and mood regulation. To sustain hippocampal neurogenesis throughout life, maintenance of the neural stem cell pool has to be tightly controlled. We found that the Notch/RBPJκ-signaling pathway is highly active in neural stem cells of the adult(More)
In the mammalian brain, neural stem and progenitor cells in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus generate new neurons throughout adulthood. The generation of new functional neurons is a complex process that is tightly controlled by extrinsic signals and that is characterized by stage-specific gene(More)
The continuous generation of new neurons from stem cells in the hippocampal dentate gyrus is considered an important contributor to hippocampal plasticity. A prerequisite for the life-long generation of new dentate granule neurons is the maintenance of the neural stem cell pool. A number of essential molecular regulators and signals for hippocampal neural(More)
This paper describes the perspective+detail visualization concept, which extends the conventional overview+detail pattern by adding a perspective viewing area and a further, text-based area containing partial details. Known problems of such extensions are mitigated using a vertically curved display. Our concept aims to bridge both the geographical and the(More)
In today's digital control rooms, desktop computers represent the most common interface for process control. Compared to their predecessors -- manual control actuators -- desktop computers enable quick and effective process intervention but they lack in process-related interaction qualities such as haptic feedback and the involvement of motor skills. Thus,(More)
In this paper, we propose Blended Interaction as a conceptual framework for the design of interactive spaces. We argue that for realizing a natural computer-supported collaboration in smart environments or interactive spaces, designers must achieve a holistic understanding and design of the users’ individual interactions, social interactions, workflows and(More)
In diesem Beitrag stellen wir eine Werkzeugkette zur Modell-getriebenen Erzeugung interaktiver Prototypen vor. Durch die konsequente Verwendung von visuellen Simulationen für funktionale und nicht-funktionale Anforderungen können Prototypen als Vehikel für eine neue Art der Systemspezifikation fungieren. Der Prozess der Anforderungsermittlung soll damit so(More)
This paper addresses the lack of interaction qualities in control rooms by investigating the potential use of Hybrid Surfaces. As an emerging trend with strong real-world references, they offer the combination of both, the qualities of physical interaction and the potentials of the digital world. To determine their applicability in the given context we(More)
Context-sensitive information is of vital importance to the monitoring of processes in control rooms, but its incorporation in current state-of-the-art user interfaces is inadequate. By looking at a traffic control center as an example, this paper proposes an interaction concept for monitoring complex networks on large remote displays. Our approach is based(More)