Tobias Schmidt

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Protein structure homology modelling has become a routine technique to generate 3D models for proteins when experimental structures are not available. Fully automated servers such as SWISS-MODEL with user-friendly web interfaces generate reliable models without the need for complex software packages or downloading large databases. Here, we describe the(More)
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein(More)
The Protein Model Portal (PMP) has been developed to foster effective use of 3D molecular models in biomedical research by providing convenient and comprehensive access to structural information for proteins. Both experimental structures and theoretical models for a given protein can be searched simultaneously and analyzed for structural variability. By(More)
In the Ninth Edition of the Critical Assessment of Techniques for Protein Structure Prediction (CASP9), 61,665 models submitted by 176 groups were assessed for their accuracy in the template based modeling category. The models were evaluated numerically in comparison to their experimental control structures using two global measures (GDT and GDC), and a(More)
Interactions between proteins and their ligands play central roles in many physiological processes. The structural details for most of these interactions, however, have not yet been characterized experientially. Therefore, various computational tools have been developed to predict the location of binding sites and the amino acid residues interacting with(More)
Intensive scientific research devoted in the recent years to understand the molecular mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new pathways and targets providing new insights and a better understanding of the molecular pathogenesis in these diseases. In this consensus manuscript, the authors discuss their current(More)
In this paper we empirically test whether public R&D subsidies crowd out private R&D investment in Flanders and Germany, using firm level data from the Flemish and German part of the Community Innovation survey (CIS III and IV). Both the non-parametric matching estimator and the conditional difference-in-difference estimator with repeated cross-sections(More)
C. Mettke-Hofmann1,2), C. Ebert3), T. Schmidt4), S. Steiger5) & S. Stieb4) (1 Max Planck Institute for Ornithology, Department of Biological Rhythms and Behaviour, Von-der-Tann-Strasse 7, 82346 Andechs, Germany; 3 University of Kaiserslautern, Dept. of Zoology, Erwin-Schrödinger-Strasse 13, 67663 Kaiserslautern, Germany; 4 Universität Würzburg, Zoologie II,(More)
Context. The star γ Cep is known as a single-lined spectroscopic triple system at a distance of 13.8 pc, composed of a K1 III-IV primary star with V = 3.2 mag, a stellar-mass companion in a 66–67 year orbit (Torres 2006), and a substellar companion with Mp sin i = 1.7 MJup that is most likely a planet (Hatzes et al. 2003). Aims. We aim to obtain a first(More)