Tobias Mayr

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393 Background: We previously reported on the discovery and prospective validation of a blood based test (Detector C) for early detection of colorectal cancer (CRC). Detector C measures 202 RNA markers in white blood cells as a response of the host to tumor formation and growth. Detector C was validated using a prospective, multicenter case-control study(More)
e14049 Background: Patients (pts) with advanced, metastatic colorectal cancer (CRC) and wild-type KRAS mutation status benefit from anti EGFR antibodies cetuximab (CE) and panitumumab. Pts with CRC of UICC stage III do not benefit from CE plus FOLFOX irrespectively of the KRAS mutation status. There is a high medical need for new biomarkers that can(More)
517 Background: wt KRAS and wt BRAF are established clinical markers to predict response to CE in patients (pts) with mCRC. Some pts with KRAS mut in codon 13 respond to CE, while the majority of them do not. Recently, it was shown that pts with CRC of Duke C and wt KRAS and wt BRAF do not benefit from CE added to FOLFOX (ASCO 2011 abstr 3607). In addition,(More)
3558 Background: Adjuvant chemotherapy in stage II colorectal cancer (CRC) is generally not recommended. Patients (pts) with T4 tumors, performations, < than 12 lymph nodes assessed, or positive vessel / lymphatic invasion may receive adjuvant chemotherapy. Following these guidelines 15-20% of the true high-risk pts remain undetected, undertreated and will(More)
e14055 Background: miRNAs have a length of 21-23 bp. They are more stable than mRNAs, especially in formalin-fixed paraffin embedded (FFPE) tumor tissue. The increased stability of miRNA makes them attractive as potential biomarkers. METHODS In the frame work of a prospective, multicenter, IRB approved study we recruited more than 4.000 patients (pts)(More)
Sirs: Photosensitive epilepsy occurs in one of approximately 3000–4000 of the population [1]. A variety of possible trigger mechanisms have been suggested. We report a case in which a seizure was provoked by the use of an “opto-acoustic relaxation system.” This “system” includes glasses that generate light flashes. After adjusting the strength of the light(More)
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